diff --git a/README.md b/README.md
index 025b5187..db13a52d 100644
--- a/README.md
+++ b/README.md
@@ -46,7 +46,7 @@ Please install the following dependencies:
  - termcolor
  - colorlog
  - packaging
- - pycryptodome
+ - pycryptodomex
 
 Example for Debian:
 ```sh
@@ -54,6 +54,7 @@ sudo apt-get install --no-install-recommends \
 	pcscd libpcsclite-dev \
 	python3 \
 	python3-setuptools \
+	python3-pycryptodome \
 	python3-pyscard \
 	python3-pip
 pip3 install --user -r requirements.txt
diff --git a/pySim/ota.py b/pySim/ota.py
index 83303a6c..5955a084 100644
--- a/pySim/ota.py
+++ b/pySim/ota.py
@@ -150,8 +150,8 @@ class OtaDialect(abc.ABC):
         pass
 
 
-from Crypto.Cipher import DES, DES3, AES
-from Crypto.Hash import CMAC
+from Cryptodome.Cipher import DES, DES3, AES
+from Cryptodome.Hash import CMAC
 
 class OtaAlgo(abc.ABC):
     iv = property(lambda self: bytes([0] * self.blocksize))
diff --git a/pySim/utils.py b/pySim/utils.py
index 6b8ee374..537014f0 100644
--- a/pySim/utils.py
+++ b/pySim/utils.py
@@ -616,9 +616,9 @@ def derive_milenage_opc(ki_hex: Hexstr, op_hex: Hexstr) -> Hexstr:
     """
     Run the milenage algorithm to calculate OPC from Ki and OP
     """
-    from Crypto.Cipher import AES
+    from Cryptodome.Cipher import AES
     # pylint: disable=no-name-in-module
-    from Crypto.Util.strxor import strxor
+    from Cryptodome.Util.strxor import strxor
     from pySim.utils import b2h
 
     # We pass in hex string and now need to work on bytes
diff --git a/requirements.txt b/requirements.txt
index fb94472f..b12cb4db 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -9,5 +9,5 @@ gsm0338
 pyyaml>=5.1
 termcolor
 colorlog
-pycryptodome
+pycryptodomex
 packaging
diff --git a/setup.py b/setup.py
index d14ebc66..d4fb15f7 100644
--- a/setup.py
+++ b/setup.py
@@ -20,7 +20,7 @@ setup(
         "pyyaml >= 5.1",
         "termcolor",
         "colorlog",
-        "pycryptodome",
+        "pycryptodomex",
         "packaging",
     ],
     scripts=[